Longevity

Experimental obesity drug reduces knee arthritis pain in a trial — Read on MedPage Today

In a 445-person trial, investigational retatrutide reduced knee osteoarthritis pain more than placebo over 68 weeks. The findings point to a potential treatment for people with knee arthritis and overweight or obesity.

Research

Experimental obesity drug reduces knee arthritis pain in a trial — Image: Solar Punk

Experimental obesity drug reduces knee arthritis pain in a trial — Image: Solar Punk

Iron infusion improves exercise capacity in patients with iron deficiency and heart failure — Show the summary

Research

Blood pressure stays lower after hormone-blocking treatment ends in small follow-up — Show the summary

Research

A supervised LSD dose reduces anxiety and depression scores in phase III trials — Show the summary

Research

Italy begins funding a targeted drug for certain slow-growing brain tumours — Read on Mondosanità

Italy’s health service began reimbursing vorasidenib on 6 November for eligible patients with IDH-mutant grade 2 glioma. The drug delayed progression in a 2023 trial, giving public funding a credible basis for widening treatment access.

Italy begins funding a targeted drug for certain slow-growing brain tumours — Image: europa.eu

Bird flu vaccine offers broader protection in mice and ferrets — Show the summary

Research

Early metformin prescription linked to lower risk of long COVID or death — Show the summary

Research

One gene-editing dose suppresses a fat-regulating protein for three years in monkeys — Show the summary

Research

Latest

FDA grants accelerated approval to drug for selected advanced head and neck cancers — Show the summary

Research

Experimental urine test detects 95% of localised bladder cancers in study — Show the summary

Research

Repatha is linked to fewer heart attacks than ezetimibe — Show the summary

Japan begins post-approval use of stem-cell-derived Parkinson’s treatment — Show the summary

Research

Two patients receive kidney transplants after experimental antibody treatment — Show the summary

Research

Lower-sodium salt could prevent nearly 3 million deaths a year, model estimates — Show the summary

Research

Brain gene therapy shows signs of reducing seizures in three-person pilot — Show the summary

Research

Flint newborn death rate halves following launch of family cash support — Show the summary

Research

Iza-bren nearly doubles time without lung cancer worsening in phase 3 trial — Show the summary

Research

Experimental compound slows growth in cancer models with a specific genetic weakness — Show the summary

Research

Gene editing corrects a disease-causing fault in one patient’s liver — Show the summary

FDA grants tentative approval to $40-a-year generic HIV prevention medicine — Show the summary

Italy’s cabinet approves bill for €300 healthcare cards for older pensioners — Show the summary

Research

Single-dose psychedelic nasal spray eases depression symptoms in phase 2 trial — Show the summary

DNA therapy wins accelerated US approval for recurring HPV-related airway growths — Show the summary

Research

Ear nerve stimulation improves lab self-control scores in men with alcohol use disorder — Show the summary

Research

Extra schooling in Britain is linked to fewer dementia diagnoses decades later — Show the summary

Research

Clot removal 24–72 hours after stroke improves disability outcomes in selected patients — Show the summary

Research

Kidney tests can disagree before breast cancer drug treatment begins — Show the summary

Italy approves public funding for gene therapy gel for fragile-skin disease — Show the summary

Preprint

Breathing carbon dioxide promotes nerve regrowth in mice — Show the summary

US judge blocks extra medical proof for Medicaid work exemptions — Show the summary

US rule requires drug middlemen to disclose payments to employer health plans — Show the summary

Research

Drug cuts new abnormal bone formations in adults with rare genetic disease — Show the summary

Research

Pancreatic cancer vaccine triggers immune responses in 89 of 90 assessed patients — Show the summary

Research

Immunotherapy alone delays progression more than chemotherapy in womb cancer trial — Show the summary

Research

Lilly reports experimental drug beats Ozempic 2 mg for weight loss in diabetes trial — Show the summary

India rejects patent bid for drug-resistant TB treatment combination — Show the summary

EU approves Enhertu after surgery for residual HER2-positive breast cancer — Show the summary

Research

Drug pair delays progression in selected patients with resistant lung cancer — Show the summary

Research

Blocking an enzyme triggers joint cartilage regrowth in mice — Show the summary

Research

First patient receives a new treatment to rewrite DNA inside the body — Show the summary

Longevity

Experimental obesity drug reduces knee arthritis pain in a trial — Read on MedPage Today

In a 445-person trial, investigational retatrutide reduced knee osteoarthritis pain more than placebo over 68 weeks. The findings point to a potential treatment for people with knee arthritis and overweight or obesity.

Research

Experimental obesity drug reduces knee arthritis pain in a trial — Image: Solar Punk

Experimental obesity drug reduces knee arthritis pain in a trial — Image: Solar Punk

Iron infusion improves exercise capacity in patients with iron deficiency and heart failure — Image: Mass General Brigham

Iron infusion improves exercise capacity in patients with iron deficiency and heart failure — Read on Mass General Brigham

In 65 people with iron deficiency and heart failure with preserved ejection fraction, one iron infusion improved exercise capacity versus placebo at 12 weeks. Peak oxygen uptake was 1.1 mL/kg/min higher, suggesting a way to improve physical function.

Research

Blood pressure stays lower after hormone-blocking treatment ends in small follow-up — Read on Medical Xpress

In an uncontrolled follow-up of 14 people with primary aldosteronism, average systolic blood pressure stayed about 25 mmHg lower after treatment ended. Improvements persisted for up to two years, suggesting a possible route to lasting remission.

Research

A supervised LSD dose reduces anxiety and depression scores in phase III trials — Read on MedPage Today

Two phase III trials presented at a conference found lower anxiety and depression scores after one supervised LSD dose than after placebo. The trials enrolled 363 people, with differences still present at 12 weeks.

Research

More to read

Italy begins funding a targeted drug for certain slow-growing brain tumours — Read on Mondosanità

Italy’s health service began reimbursing vorasidenib on 6 November for eligible patients with IDH-mutant grade 2 glioma. The drug delayed progression in a 2023 trial, giving public funding a credible basis for widening treatment access.

Bird flu vaccine offers broader protection in mice and ferrets — Read on Euronews

An experimental bird flu vaccine produced broader immune responses and better protection in mice and ferrets than selected strain-specific vaccine antigens. The results offer a research route towards broader pandemic protection.

Research

Early metformin prescription linked to lower risk of long COVID or death — Read on Medical Xpress

In an observational study, metformin prescribed within six days of COVID-19 was linked to a 53% lower six-month risk of long COVID or death. The finding adds evidence on a possible preventive role for the diabetes drug.

Research

One gene-editing dose suppresses a fat-regulating protein for three years in monkeys — Read on BioPharma Dive

In monkeys, one infusion cut ANGPTL3 protein by over 90% on average, sustained through three years. Animal models also showed lower LDL cholesterol and triglycerides, supporting research into a single-dose treatment.

Research

Latest

FDA grants accelerated approval to drug for selected advanced head and neck cancers — Show the summary

Research

Experimental urine test detects 95% of localised bladder cancers in study — Show the summary

Research

Repatha is linked to fewer heart attacks than ezetimibe — Show the summary

Japan begins post-approval use of stem-cell-derived Parkinson’s treatment — Show the summary

Research

Two patients receive kidney transplants after experimental antibody treatment — Show the summary

Research

Lower-sodium salt could prevent nearly 3 million deaths a year, model estimates — Show the summary

Research

Brain gene therapy shows signs of reducing seizures in three-person pilot — Show the summary

Research

Flint newborn death rate halves following launch of family cash support — Show the summary

Research

Iza-bren nearly doubles time without lung cancer worsening in phase 3 trial — Show the summary

Research

Experimental compound slows growth in cancer models with a specific genetic weakness — Show the summary

Research

Gene editing corrects a disease-causing fault in one patient’s liver — Show the summary

FDA grants tentative approval to $40-a-year generic HIV prevention medicine — Show the summary

Italy’s cabinet approves bill for €300 healthcare cards for older pensioners — Show the summary

Research

Single-dose psychedelic nasal spray eases depression symptoms in phase 2 trial — Show the summary

DNA therapy wins accelerated US approval for recurring HPV-related airway growths — Show the summary

Research

Ear nerve stimulation improves lab self-control scores in men with alcohol use disorder — Show the summary

Research

Extra schooling in Britain is linked to fewer dementia diagnoses decades later — Show the summary

Research

Clot removal 24–72 hours after stroke improves disability outcomes in selected patients — Show the summary

Research

Kidney tests can disagree before breast cancer drug treatment begins — Show the summary

Italy approves public funding for gene therapy gel for fragile-skin disease — Show the summary

Preprint

Breathing carbon dioxide promotes nerve regrowth in mice — Show the summary

US judge blocks extra medical proof for Medicaid work exemptions — Show the summary

US rule requires drug middlemen to disclose payments to employer health plans — Show the summary

Research

Drug cuts new abnormal bone formations in adults with rare genetic disease — Show the summary

Research

Pancreatic cancer vaccine triggers immune responses in 89 of 90 assessed patients — Show the summary

Research

Immunotherapy alone delays progression more than chemotherapy in womb cancer trial — Show the summary

Research

Lilly reports experimental drug beats Ozempic 2 mg for weight loss in diabetes trial — Show the summary

India rejects patent bid for drug-resistant TB treatment combination — Show the summary

EU approves Enhertu after surgery for residual HER2-positive breast cancer — Show the summary

Research

Drug pair delays progression in selected patients with resistant lung cancer — Show the summary

Research

Blocking an enzyme triggers joint cartilage regrowth in mice — Show the summary

Research

First patient receives a new treatment to rewrite DNA inside the body — Show the summary